Back in April, I wrote about changing the path of Integration Manager Database for a user. There is now a new KB article out(953217), which gives quicker steps to set the location for ALL users.
You basically go in and add a switch in the Microsoft.Dynamics.GP.IntegrationManager.ini file.
Mark pointed out correctly in the comments, there are often very few users and its normally easy to set this from the User Interface.
This trick, however, can be helpful in cases when you are setting up integration manager on a terminal server. Often after upgrades, I have had to manually set the path for each user, one by one. And when multiple terminal servers are set up - this becomes even more difficult.
This is a big help in those cases.