I saw this error in the GP Community Forum. After a fresh IM 2010 install, when you launch Integration Manager you might get the following error - Could not create all default application data due to the following error – Access to the path ‘C:\ProgramData\Microsoft\Microsoft Dynamics GP\188.8.131.52’ is denied.
My first reaction was to check the path in “Tools > Options”, It had the correct path – in the default case - “C:\Program Files\Microsoft Dynamics\Integration Manager 11\Samples\IntegrationManagerSamples.IMD”
I thought of re-installing, but before I did that I just launched Integration Manager with “Run as Administrator” option, and that resolved the error. IM 2010 writes an XML file in the “C:\ProgramData\Microsoft\Microsoft Dynamics GP\184.108.40.206” folder so you need access to write to that folder.